Israel’s Sheba Medical Center on Monday began the world’s first trial of a fourth dose of the Pfizer-BioNTech COVID-19 vaccine.

Sheba, the largest medical center in Israel and the Middle East, recruited 150 employees for the study. Each had received a third, “booster” dose in August but now has a low antibody count of below 700, according to a hospital spokesman.

Led by Dr. Gili Regev-Yochay, director of Sheba’s Infectious Disease Epidemiology Unit, the study was approved by the Health Ministry’s Helsinki Committee, which oversees human medical trials.

Although the U.S. Food and Drug Administration has not yet approved a fourth Pfizer shot, Israel’s Pandemic Expert Committee wants to administer fourth shots to medical personnel and citizens over age 60, because the protection offered by the third dose seems to wear off at six months.

Regev-Yochay said her goal is to determine whether the fourth dose is effective in stimulating the production of antibodies and whether it is safe.

“This study is expected to shed light on the additional benefit of giving a fourth dose. We will [seek to] understand whether, and to whom, it is worth giving a fourth dose,” she said. “We will have safety data within a few days.”

The results will help guide Israel’s policy and that of the rest of the world as the Omicron variant is causing a new wave of infections. Many experts believe the current formulation of the vaccine is ineffective against Omicron.

The first to receive the shot was heart transplant surgeon Dr. Jacob Lavee, who said it was “one small jab in the shoulder but one giant leap for mankind in the global battle against the Covid infection.”

Israeli Prime Minister Naftali Bennett noted that “Israel is continuing to stand at the forefront of the global effort to deal with the pandemic. The citizens of Israel were the first in the world to receive the third dose of the Covid-19 vaccine and we are continuing to pioneer with the fourth dose as well.”

This article was first published by Israel21c.


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